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Published on: June 26, 2020
Research trends of stem cells in ischemic stroke from 1999 to 2018: A bibliometric analysis
Chengxian Yang1, Xue Wang2, Xiaoli Tang2
1Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.
Insights
Research on stem cell therapy for ischemic stroke has surged, with over 3,700 publications between 1999-2018. Neural and mesenchymal stem cells show the most promise for clinical translation.
Area of Science:
- Biomedical research
- Regenerative medicine
- Neurology
Background:
- Stem cell therapy is a promising treatment for ischemic stroke.
- Evaluating research trends is crucial for understanding the field's progression.
Purpose of the Study:
- To quantitatively assess research trends in stem cell therapy for ischemic stroke.
- To identify key publications, authors, countries, institutions, and evolving topic hotspots.
Main Methods:
- Bibliometric analysis of 3,741 publications from 1999-2018 using Web of Science Core Collection.
- HistCite for data summarization and VOSviewer for collaboration mapping.
- Medical Text Indexer for MeSH term extraction to identify topic evolution.
Main Results:
- Publication output increased significantly from 6 to 366 articles annually.
- The United States and China are leading contributors.
- Neural stem cells and mesenchymal stem cells are prominent in clinical translation research.
- 'Stroke' is a highly influential journal in this field.
Conclusions:
- Bibliometrics provides valuable insights into academic collaborations, research trends, and hot topics in stem cell therapy for ischemic stroke.
- The field is rapidly expanding, highlighting the growing interest and investment in this therapeutic approach.
Objective:
Many studies have evaluated the safety and efficacy of stem cells as therapeutic agents for ischemic stroke. We aimed to quantitatively assess the research trends of stem cell therapy for ischemic stroke.
Patients And Methods:
We searched the Web of Science Core Collection to identify relevant publications between 1999 and 2018. We used HistCite to summarize the critical information, including yearly records, authors, countries/regions, and institutions. VOSviewer was applied to map the collaborations between studies. Based on the title and abstract of each publication, MeSH terms were obtained using Medical Text Indexer to demonstrate evolutions of topic hotspots.
Results:
From 1999-2018, there were a total of 3,741 publications exploring the prospect of stem cells in ischemic stroke. Annual publication outputs grew from six records to 366 records. Stroke was the most high-profile journal because of its ranking first on the top productive and co-cited journal lists. The United States of America and China were the two most contributive countries of stem-cell research of ischemic stroke. Researchers were supposed to follow studies from productive institutions because of their consistent and systematic investigations in this field. Neural stem cells and mesenchymal stem cells were the most recognized cells for clinical translation.
Conclusion:
With the growth of publications concerning the role of stem cells in ischemic stroke treatment, bibliometrics helps researchers to get insights of academic collaborations, research trends, and hot topics in the study field.
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