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Association of N6-methyladenosine with viruses and virally induced diseases

Fang Wu1, Wenzhao Cheng1, Feiyuan Zhao1

  • 1Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University, Xiamen, China.

Frontiers in Bioscience (Landmark Edition)
|March 2, 2020
PubMed

Insights

N6-methyladenosine (m6A) modification regulates gene expression and is implicated in viral diseases. Understanding m6A

Area of Science:

  • Molecular Biology
  • Virology
  • Epigenetics

Background:

  • N6-methyladenosine (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA).
  • m6A modification is a dynamic and reversible process regulated by writers, erasers, and readers.
  • m6A plays a crucial role in various RNA metabolism stages, including structure, stability, splicing, export, translation, and degradation.

Purpose of the Study:

  • To review the role of m6A modification in gene expression.
  • To explore the contribution of m6A to the development of human viral diseases.
  • To identify novel therapeutic strategies for viral infections by examining m6A's involvement.

Main Methods:

  • Literature review of existing studies on m6A modification and viral diseases.
  • Analysis of m6A's regulatory mechanisms in RNA processing.
  • Focus on specific human viruses such as HIV-1, IAV, HBV, HCV, and EBV.

Main Results:

  • Abnormal m6A levels are linked to aberrant expression of viral genes.
  • m6A modification influences the life cycle and pathogenesis of various human viruses.
  • Specific viral examples include HIV-1, Influenza A virus (IAV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Epstein-Barr virus (EBV).

Conclusions:

  • m6A modification is a significant factor in the pathogenesis of human viral diseases.
  • Targeting m6A regulatory pathways presents a promising avenue for innovative antiviral therapies.
  • Further research into m6A's role can provide new insights for treating viral infections.

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