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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Epigenetic regulation as a promising tool for treatment of atherosclerosis

Daria Alexandrovna Skuratovskaia1, Maria Alexandrovna Vulf2, Aleksandra Komar2

  • 1Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation, Russia, DSkuratovskaya@kantiana.ru.

Frontiers in Bioscience (Scholar Edition)
|March 2, 2020
PubMed

Insights

Epigenetic therapies using noncoding RNAs (ncRNAs) offer novel treatments for atherosclerosis, a major cause of cardiovascular disease. These approaches target lipid metabolism and inflammation, with some showing promise in clinical trials.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Genetics

Background:

  • Atherosclerosis is a leading cause of cardiovascular disease (CVD) mortality.
  • It involves lipid metabolism disruption and chronic inflammation in arteries.
  • Epigenetic modifications by noncoding RNAs (ncRNAs) are implicated in its pathogenesis.

Purpose of the Study:

  • To review the therapeutic potential of ncRNAs in treating atherosclerosis.
  • To explore the use of miRNA antagonists, mimics, and other ncRNAs.
  • To discuss clinical trial progress and future applications of these epigenetic strategies.

Main Methods:

  • Review of current literature on ncRNA-based atherosclerosis treatments.
  • Analysis of miRNA, siRNA, and lncRNA applications.
  • Examination of clinical trial data for emerging therapies.

Main Results:

  • ncRNA-based therapies, including miRNA antagonists and mimics, are effective in preclinical models.
  • Specific activation of atheroprotective miRNAs shows therapeutic promise.
  • siRNAs and lncRNAs can modulate aberrant lipid metabolism.

Conclusions:

  • Epigenetic regulation by ncRNAs represents a promising therapeutic avenue for atherosclerosis.
  • Several ncRNA-based strategies are advancing through clinical trials.
  • These novel treatments are poised to enter clinical practice for cardiovascular disease management.

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