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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Urinary Tract Calculi I: Introduction01:28

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Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
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Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

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Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
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Uterine Tubes01:16

Uterine Tubes

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The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Endometrial Calcifications.

Badr AbdullGaffar1, Amal AlMulla2

  • 1Rashid Hospital, Dubai, United Arab Emirates.

International Journal of Surgical Pathology
|March 3, 2020
PubMed
Summary

Benign endometrial calcifications are rare findings, often linked to infertility and menstrual issues in women. Pathologic identification is crucial for diagnosis and patient management.

Area of Science:

  • Gynecologic Pathology
  • Reproductive Endocrinology

Background:

  • Benign endometrial calcifications are uncommon clinicopathologic findings.
  • Associated with infertility and menstrual anomalies in various patient groups.
  • Etiology and pathogenesis remain unclear, with debated clinical significance.

Purpose of the Study:

  • To review cases of benign endometrial calcifications.
  • To compare benign calcifications with malignant endometrial calcifications.
  • To highlight the clinical importance of accurate pathologic recognition.

Main Methods:

  • Retrospective review of 11 cases of benign endometrial calcifications over 7 years.
  • Analysis of patient demographics, clinical presentations, and histomorphologic patterns.
  • Inclusion of cases with endometrial malignancies for comparative analysis.
Keywords:
atrophicbenignbonecalcificationendometriuminfertilitymalignantpsammoma bodies

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Main Results:

  • 11 cases (0.4%) identified, with a mean patient age of 45.2 years.
  • All patients presented with menstrual abnormalities; 4 reported infertility.
  • Varied histomorphologic patterns observed, with associations to endometrial polyps and other conditions.

Conclusions:

  • Pathologic recognition is clinically important for diagnosis and management.
  • Benign endometrial calcifications can be a treatable cause of infertility.
  • Understanding histomorphologic variations is key to avoid diagnostic pitfalls.