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Updated: Dec 27, 2025

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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Early-life programming of adipose tissue.

Ericka Moreno-Mendez¹, Saray Quintero-Fabian^1,2, Cristina Fernandez-Mejia¹

¹Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, Mexico.

Nutrition Research Reviews

|March 3, 2020

Summary

Maternal factors during pregnancy significantly influence childhood obesity by programming adipose tissue development. Understanding these early-life influences is key to preventing obesity across generations.

Keywords:

Adipose tissue Developmental origins of health and disease Fetal programming Maternal obesity

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Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Published on: January 25, 2021

Area of Science:

Metabolic health
Developmental biology
Endocrinology

Background:

Childhood obesity is a growing global health crisis with serious co-morbidities.
The maternal environment during pregnancy is critical for metabolic programming and can influence obesity transmission across generations.
White adipose tissue is a key target for metabolic programming influenced by the maternal environment.

Purpose of the Study:

To review adipose tissue physiology and development.
To examine maternal influences during the perinatal period on obesity development.
To discuss how maternal factors impact fetal growth and adiposity.

Main Methods:

Review of current literature on adipose tissue physiology and development.
Analysis of hormonal factors in fetal/postnatal programming.
Examination of maternal nutritional, hormonal, epigenetic, and microbiome changes in obesity.

Main Results:

Adipose tissue development is sensitive to nutritional, hormonal, and epigenetic signals during critical gestational and early postnatal periods.
Maternal obesity and associated changes can disrupt fetal growth and adiposity.
Evidence supports the developmental origins of health and disease concept linking early-life programming to adult obesity.

Conclusions:

Early-life adipose tissue programming by maternal factors is crucial for long-term metabolic health.
Understanding these mechanisms offers potential strategies for combating the global obesity epidemic.
Interventions promoting healthy early-life programming may prevent obesity in future generations.