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Related Concept Videos

Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
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Parasympathetic Signaling01:30

Parasympathetic Signaling

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Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Pain: Pathways and Physiology.

Greg I Lee1, Michael W Neumeister1

  • 1Southern Illinois University School of Medicine, SIU Plastic Surgery, 747 North Rutledge 3rd Floor, PO Box 19653, Springfield, IL 62794, USA.

Clinics in Plastic Surgery
|March 3, 2020
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Summary
This summary is machine-generated.

Pain signals travel between the body and brain through specific pathways. Understanding these pain pathways is key to developing targeted pain treatments.

Keywords:
Acute painChronic painNeuropathic painPain

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Area of Science:

  • Neuroscience
  • Pain Medicine
  • Anatomy

Background:

  • Pain perception is a complex process involving peripheral and central nervous system interactions.
  • Specific neural pathways transmit pain signals, influencing their modulation and effects.
  • Understanding these pathways is crucial for effective pain management.

Purpose of the Study:

  • To review the anatomy and physiology of pain signaling.
  • To highlight key pathways involved in pain transmission.
  • To emphasize targeted treatment strategies for pain.

Main Methods:

  • Literature review of anatomical and physiological studies on pain.
  • Analysis of neural pathways involved in pain signaling.
  • Synthesis of information on pain modulation and treatment targets.

Main Results:

  • Detailed description of the anatomical structures and physiological processes of pain.
  • Identification of critical neural pathways for pain signal transmission.
  • Overview of how these pathways can be targeted for therapeutic intervention.

Conclusions:

  • Pain management requires a thorough understanding of its underlying neuroanatomy and physiology.
  • Targeting specific pain pathways offers a promising approach for novel pain therapies.
  • Further research into pain pathway modulation can lead to improved patient outcomes.