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Updated: Dec 27, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Complex Regional Pain Syndrome.

Michael W Neumeister¹, Michael R Romanelli²

¹Department of Surgery, Institute for Plastic Surgery, Southern Illinois University School of Medicine, Southern Illinois University, 747 North Rutledge Street, Suite 357, Baylis Building, Springfield, IL 62702, USA.

Clinics in Plastic Surgery

|March 3, 2020

Summary

This summary is machine-generated.

Complex regional pain syndrome (CRPS) is a hyperalgesic condition causing disproportionate pain and autonomic dysfunction. This review covers the diagnosis and treatment of CRPS, a complex pain disorder.

Keywords:

CRPS Causalgia Complex regional pain RSD

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Area of Science:

Pain Medicine
Neurology
Rehabilitation Medicine

Background:

Complex regional pain syndrome (CRPS) is characterized by pain disproportionate to the inciting event.
It involves autonomic dysfunction, swelling, skin changes, stiffness, and functional impairment, primarily affecting the upper extremities.
The underlying pathophysiology involves a sensitized and overactive pain pathway from peripheral to central nervous system, disrupting autonomic responses.

Purpose of the Study:

To review the current understanding of Complex regional pain syndrome (CRPS).
To outline the diagnostic criteria and approaches for CRPS.
To discuss the available treatment strategies for managing CRPS.

Main Methods:

Literature review of existing studies on CRPS.
Synthesis of information regarding CRPS pathophysiology, diagnosis, and treatment.
Analysis of clinical manifestations and diagnostic challenges.

Main Results:

CRPS presents with a distinct set of symptoms including severe pain, edema, and altered skin characteristics.
Diagnosis relies on clinical presentation and exclusion of other conditions, as objective biomarkers are limited.
Treatment is multimodal, often involving pharmacotherapy, physical therapy, and psychological support.

Conclusions:

CRPS is a complex, debilitating pain syndrome requiring a comprehensive diagnostic and therapeutic approach.
Further research into the etiology and pathophysiology of CRPS is needed to develop more targeted treatments.
Early diagnosis and intervention are crucial for improving functional outcomes in patients with CRPS.