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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Promising antifungal agents: A minireview

K V S Mani Chandrika1, Sahida Sharma1

  • 1Department of Chemistry, Sri Sathya Sai Institute of Higher Learning, Anantapur Campus, Anantapur 515001, A.P., India.

Bioorganic & Medicinal Chemistry
|March 3, 2020
PubMed

Insights

Rising fungal infections and drug resistance necessitate novel antifungal agents. This review explores new drug design strategies, structure-activity relationships, and mechanisms of action for effective treatments.

Area of Science:

  • Medical Mycology
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Increasing incidence of life-threatening fungal diseases in immunocompromised patients (e.g., AIDS, cancer, organ transplant recipients).
  • Growing challenge of antifungal drug resistance, limiting current therapeutic options.

Purpose of the Study:

  • To review methodologies for designing new antifungal agents.
  • To discuss structure-activity relationships (SARs) of novel antifungal compounds.
  • To explore the modes of action for emerging antifungal therapeutics.

Main Methods:

  • Literature review of antifungal drug discovery and development.
  • Analysis of structure-activity relationships (SARs) in antifungal agents.
  • Examination of pharmacological targets and mechanisms of action.

Main Results:

  • Identification of key pharmacological interactions for rational drug design.
  • Overview of diverse strategies for developing broad-spectrum antifungal agents.
  • Highlighting the importance of minimizing toxicity in new antifungal drug candidates.

Conclusions:

  • Understanding drug-target interactions is crucial for designing effective antifungals.
  • New antifungal agents are needed to overcome resistance and reduce toxicity.
  • This review provides insights into current approaches for novel antifungal drug discovery.
Keywords:
Antifungal agentsAntifungal targetsMinimum Inhibitory Concentration (MIC)Structure activity relationships (SARs)Zone of inhibition (Z.I)

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