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Related Concept Videos

Coagulation01:09

Coagulation

9.4K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

Updated: Dec 27, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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The Year in Coagulation: Selected Highlights From 2019.

Michael A Mazzeffi1, Prakash A Patel2, Daniel Bolliger3

  • 1Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD.

Journal of Cardiothoracic and Vascular Anesthesia
|March 3, 2020
PubMed
Summary

This review covers key 2019 coagulation literature for cardiothoracic and vascular anesthesia. It highlights management of perioperative bleeding, hemostasis, and coagulopathy during mechanical circulatory support.

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Area of Science:

  • Cardiovascular Anesthesia
  • Coagulation Science
  • Hematology

Background:

  • The Journal of Cardiothoracic and Vascular Anesthesia introduces its first annual review of significant coagulation literature.
  • Coagulation management is critical in cardiothoracic and vascular procedures.

Purpose of the Study:

  • To summarize and analyze the most impactful coagulation research published in 2019.
  • To provide an overview of advancements relevant to perioperative hemostasis and bleeding management.

Main Methods:

  • Comprehensive literature review of coagulation studies from 2019.
  • Analysis of guidelines and clinical practice advisories.
  • Synthesis of information on specific topics including heparin monitoring and factor concentrates.

Main Results:

  • Discussion of the Society of Cardiovascular Anesthesiologists clinical practice advisory on bleeding and hemostasis.
  • Review of literature on heparin monitoring and protamine dosing.
  • Examination of antiplatelet therapy, factor concentrate use, and coagulopathy in mechanical circulatory support.

Conclusions:

  • The reviewed literature provides essential updates for managing coagulation in cardiothoracic and vascular patients.
  • Key areas of focus include evidence-based practices for bleeding management and coagulopathy during mechanical circulatory support.