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Related Concept Videos

Aging01:26

Aging

518
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
518
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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[Multidisciplinary Approach to Aging].

Ryoya Takahashi1, Keiko Odera1

  • 1Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|March 3, 2020
PubMed
Summary
This summary is machine-generated.

Aging causes physiological decline, impacting daily life and quality of life (QOL) for seniors. Research into aging mechanisms and interventions for age-associated diseases requires a multidisciplinary approach.

Keywords:
agingcalorie restrictionhealthy life expectancystrain difference

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Area of Science:

  • Gerontology and Physiology
  • Biomedical Research

Background:

  • Physiological functions decline with age, affecting elderly individuals' activities of daily living (ADL) and quality of life (QOL).
  • Understanding the mechanisms of aging is a critical area of scientific investigation.

Purpose of the Study:

  • To review the current state of aging research.
  • To highlight the necessity of a multidisciplinary approach in gerontology.

Main Methods:

  • Literature review of aging mechanisms.
  • Discussion of interventions for age-associated diseases.

Main Results:

  • Age-related functional decline significantly impacts elderly populations.
  • Novel strategies to attenuate or delay human aging are under active investigation.

Conclusions:

  • A comprehensive, multidisciplinary approach is essential for advancing aging research.
  • Further research is needed to develop effective interventions for age-associated conditions.