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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Related Experiment Video

Updated: Dec 27, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Monocyte/HDL ratio predicts hypertensive complications.

I G Kaplan, M Kaplan, O O Abacioglu

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    |March 3, 2020
    PubMed
    Summary

    The monocyte/HDL ratio (MHR) can predict end-organ damage in hypertension patients and distinguish between dipper and non-dipper hypertension. Higher MHR indicates increased risk for complications like left ventricular hypertrophy and retinopathy.

    Keywords:
    dippermonocyte/HDL rationon-dipper hypertensive complications.

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    Area of Science:

    • Cardiology
    • Nephrology
    • Ophthalmology

    Background:

    • Hypertension management requires effective tools for predicting end-organ damage.
    • Non-dipper hypertension (NDHT) is associated with increased cardiovascular risk and end-organ damage compared to dipper hypertension (DHT).
    • The monocyte/HDL ratio (MHR) is a potential inflammatory marker.

    Purpose of the Study:

    • To evaluate the monocyte/HDL ratio (MHR) as a predictor of end-organ damage in hypertensive patients.
    • To determine if MHR can differentiate between non-dipper (NDHT) and dipper (DHT) hypertension.
    • To explore the association between MHR and specific end-organ damage markers.

    Main Methods:

    • Ambulatory blood pressure monitoring was used to classify 70 NDHT and 73 DHT patients.
    • Laboratory parameters and spot urine analysis were performed.
    • Transthoracic echocardiography and ophthalmological examinations assessed end-organ damage.

    Main Results:

    • MHR was significantly higher in the NDHT group compared to the DHT group (p≤0.001).
    • NDHT patients showed higher urinary albumin, creatinine, protein, and protein/creatinine ratios (p≤0.05).
    • Left ventricular hypertrophy (LVH) and retinopathy were more prevalent in the NDHT group (p≤0.001). MHR was significantly higher in patients with LVH and retinopathy (p=0.001).

    Conclusions:

    • The MHR is a simple, non-invasive marker for predicting end-organ damage in hypertension.
    • MHR can effectively distinguish between dipper and non-dipper hypertension.
    • Elevated MHR supports the role of inflammation in hypertension-related end-organ damage.