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Published on: June 17, 2020
Systems analysis of benign bladder disorders: insights from omics analysis
Ali Hashemi Gheinani1,2, Alexander Bigger-Allen1,3, Amanda Wacker1,4
1Department of Urology, Boston Children's Hospital, Boston, Massachusetts.
Abstract:
The signaling pathways and effectors that drive the response of the bladder to nonmalignant insults or injury are incompletely defined. Interrogation of biological systems has been revolutionized by the ability to generate high-content data sets that capture information on a variety of biomolecules in cells and tissues, from DNA to RNA to proteins. In oncology, such an approach has led to the identification of cancer subtypes, improved prognostic capability, and has provided a basis for precision treatment of patients. In contrast, systematic molecular characterization of benign bladder disorders has lagged behind, such that our ability to uncover novel therapeutic interventions or increase our mechanistic understanding of such conditions is limited. Here, we discuss existing literature on the application of omics approaches, including transcriptomics and proteomics, to urinary tract conditions characterized by pathological tissue remodeling. We discuss molecular pathways implicated in remodeling, challenges in the field, and aspirations for omics-based research in the future.
Insights
Molecular insights into benign bladder disorders are limited. Omics approaches like transcriptomics and proteomics offer new avenues for understanding bladder tissue remodeling and developing therapies.
Area of Science:
- Urology
- Molecular Biology
- Pathology
Background:
- Signaling pathways in bladder injury response are not fully understood.
- High-content omics data have transformed cancer research but not benign bladder disorders.
- Limited molecular characterization hinders understanding and treatment of benign bladder conditions.
Purpose of the Study:
- To review the application of omics approaches in urinary tract conditions with pathological tissue remodeling.
- To highlight molecular pathways involved in bladder remodeling.
- To discuss challenges and future directions for omics research in benign bladder disorders.
Main Methods:
- Literature review of omics studies (transcriptomics, proteomics) in urinary tract conditions.
- Focus on studies involving pathological tissue remodeling.
- Analysis of molecular pathways implicated in disease.
Main Results:
- Omics approaches provide deep molecular insights into benign bladder disorders.
- Transcriptomics and proteomics reveal key pathways in pathological tissue remodeling.
- Systematic molecular characterization is crucial for advancing mechanistic understanding.
Conclusions:
- Omics technologies are essential for unraveling the molecular basis of benign bladder disorders.
- Future research should leverage omics to identify novel therapeutic targets and improve patient outcomes.
- Bridging the gap in molecular understanding is critical for developing effective interventions.
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