Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present
Su-Min Wu1, Xiao-Yang Qiu1,2, Shu-Juan Liu1
1College of Science & Technology, Ningbo University, Ningbo, 315212, China.
Abstract:
Inhibitors of monoamine oxidase (MAO) have shown therapeutic values in a variety of neurodegenerative diseases such as depression, Parkinson's disease and Alzheimer's disease. Heterocyclic compounds exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel single heterocyclic derivatives with MAO inhibitory activities during the past decade. This review covers recent pharmacological advancements of single heterocyclic moiety along with structure- activity relationship to provide better correlation among different structures and their receptor interactions.
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