Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synaptic Signaling01:09

Synaptic Signaling

6.4K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
6.4K
Synaptic Signaling01:12

Synaptic Signaling

78.9K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
78.9K
The Synapse02:47

The Synapse

132.2K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
132.2K
Integration of Synaptic Events01:28

Integration of Synaptic Events

3.3K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.3K
Overview of Synapses01:25

Overview of Synapses

4.5K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
4.5K
Neural Circuits01:25

Neural Circuits

2.5K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the anti-inflammatory mechanism of <i>Dolichos lablab</i> flower extract: synergistic action of bioactive flavonoids <i>via</i> multi-target modulation.

Food & function·2026
Same author

Case Report: First occurrence of smoldering multiple myeloma in activated phosphoinositide 3-Kinase δ syndrome.

Frontiers in oncology·2026
Same author

Effect of Pore Structure Parameters on Thermal Insulation Performance of Porous Ceramics Fabricated by Material Jetting.

Materials (Basel, Switzerland)·2026
Same author

Research Progress on Preparation Technology, Structure Optimization and Properties of 3D-Printed Porous Ceramics.

Materials (Basel, Switzerland)·2026
Same author

Infrared radiation-assisted drying stabilizes rice flavor by modulating volatile composition and lipid metabolism.

Food chemistry·2026
Same author

Metagenomic profiling of biliary microbiota reveals distinct microbial and functional features in cholelithiasis and cholecystic polyps.

Medicine·2026
Same journal

Calcium at the crossroads of the immunometabolic signaling and comorbidity in schizophrenia.

Frontiers in synaptic neuroscience·2026
Same journal

Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer's disease: phytochemicals as neuroprotective agents.

Frontiers in synaptic neuroscience·2026
Same journal

NMDA receptors play an important role in postictal potentiation in immature rats.

Frontiers in synaptic neuroscience·2026
Same journal

Suicidality as a potential risk and therapeutic target during widespread GLP-1 receptor agonists use: implications of inflammation.

Frontiers in synaptic neuroscience·2026
Same journal

NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons.

Frontiers in synaptic neuroscience·2026
Same journal

Automated ROI detection allows rapid quantification of synaptic activity across tens of thousands of synapses in cell culture.

Frontiers in synaptic neuroscience·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.8K

Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.

Guanxiao Qi1, Danqing Yang1, Chao Ding1

  • 1Institute of Neuroscience and Medicine, INM-10, Jülich Research Centre, Jülich, Germany.

Frontiers in Synaptic Neuroscience
|March 3, 2020
PubMed
Summary
This summary is machine-generated.

Paired recordings offer a comprehensive method for studying synaptic transmission between neurons. This technique enables detailed functional and structural analysis of neural connections, crucial for understanding brain information processing.

Keywords:
neuromodulationpaired recordingsquantal analysisstructure-function analysissynaptic connection

More Related Videos

Paired Whole Cell Recordings in Organotypic Hippocampal Slices
09:23

Paired Whole Cell Recordings in Organotypic Hippocampal Slices

Published on: September 28, 2014

15.2K
Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

11.9K

Related Experiment Videos

Last Updated: Dec 27, 2025

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
10:24

Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

17.8K
Paired Whole Cell Recordings in Organotypic Hippocampal Slices
09:23

Paired Whole Cell Recordings in Organotypic Hippocampal Slices

Published on: September 28, 2014

15.2K
Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

11.9K

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Synaptic Plasticity

Background:

  • Synaptic transmission is fundamental to neural information processing in cortical microcircuits.
  • Paired recording is a key technique for analyzing neuronal connections.

Purpose of the Study:

  • To review the diverse applications of paired recordings in neuroscience.
  • To highlight the utility of paired recordings for characterizing synaptic function and structure.

Main Methods:

  • Paired recordings from synaptically coupled neurons.
  • Electrophysiological and anatomical characterization.
  • Light and electron microscopy.

Main Results:

  • Paired recordings provide detailed electrophysiological and anatomical data on coupled neurons.
  • This method allows for quantal analysis and investigation of neuromodulatory effects.
  • It is essential for understanding connectivity rules and synaptic dynamics.

Conclusions:

  • Paired recordings are indispensable for detailed synaptic transmission characterization.
  • This technique is valuable across species, including humans.
  • It remains a cornerstone for advancing our understanding of neural circuits.