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Related Experiment Video

Updated: Dec 27, 2025

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
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Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data.

Alain Boussuges1,2, Sarah Rives1,2, Marion Marlinge2

  • 1ERRSO, Institut de Recherche Biomédicale des Armées (IRBA), Toulon, France.

Frontiers in Physiology
|March 3, 2020
PubMed
Summary

Hyperoxia, or breathing pure oxygen, lowers adenosine levels at rest but does not fully prevent their rise during low-intensity exercise. This impacts cardiovascular responses like heart rate and blood pressure.

Keywords:
cardiac outputcirculatory systemechocardiographyhyperemiaoxygensystemic vascular resistances

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Respiratory Physiology

Background:

  • Adenosine, an ATP derivative, plays a key role in the cardiovascular system's adaptation to exercise.
  • This study investigated the effect of hyperoxic exposure on the adenosinergic pathway during exercise.

Purpose of the Study:

  • To test the hypothesis that hyperoxia counteracts exercise-induced hyperemia by downregulating the adenosinergic pathway.
  • To examine the impact of breathing medical air versus pure oxygen on adenosine plasma levels and hemodynamic responses during rest and exercise.

Main Methods:

  • Ten healthy volunteers participated in randomized sessions involving rest and exercise (40% maximal intensity) under medical air or oxygen.
  • Adenosine plasma levels (APL) and hemodynamic parameters (cardiac output, systemic vascular resistance) were measured.

Main Results:

  • Hyperoxia significantly reduced resting APL, heart rate, and cardiac output, while increasing systemic vascular resistance.
  • During exercise, APL increased in both conditions but was significantly lower under hyperoxia compared to medical air.
  • Hemodynamic differences observed during exercise under hyperoxia (increased SVR, decreased heart rate and CO) align with reduced APL.

Conclusions:

  • Hyperoxia decreases adenosine plasma levels at rest in healthy individuals.
  • Breathing pure oxygen does not abolish the exercise-induced increase in adenosine plasma levels or the decrease in systemic vascular resistance during low-intensity exercise.