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Related Concept Videos

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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Immune Surveillance by NK Cells and Phagocytes

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Updated: Dec 27, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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KSHV: Immune Modulation and Immunotherapy.

Grant Broussard1,2, Blossom Damania1,2,3

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Frontiers in Immunology
|March 3, 2020
PubMed
Summary
This summary is machine-generated.

Kaposi

Keywords:
KSHVcytokinesimmune system modulationimmunotherapyinterferononcoviruses

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Area of Science:

  • Virology and Immunology
  • Oncology

Background:

  • Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) drives KS, PEL, and MCD.
  • KSHV establishes lifelong latent infections by subverting host immune defenses.
  • Immune evasion by KSHV facilitates the development of associated cancers.

Purpose of the Study:

  • To review KSHV immune evasion mechanisms.
  • To discuss current immunotherapeutic strategies for KSHV-associated malignancies.

Main Methods:

  • Literature review of KSHV pathogenesis and immune response.
  • Analysis of clinical data on immunotherapy for KSHV-associated diseases.

Main Results:

  • KSHV utilizes a complex viral protein network to manipulate host immunity.
  • Successful immune modulation by KSHV enables viral persistence and oncogenesis.
  • Immunotherapy shows promise for treating KSHV-driven cancers.

Conclusions:

  • Understanding KSHV's immune evasion is crucial for developing effective treatments.
  • Targeting KSHV-mediated immune dysregulation offers a viable therapeutic avenue for KSHV-associated malignancies.