Related Experiment Video
Updated: Dec 27, 2025
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
1.3K
NK Cell-Based Immune Checkpoint Inhibition.
Muhammad Khan1, Sumbal Arooj2, Hua Wang1
1Department of Oncology, The First Affiliated Hospital, Institute for Liver Diseases of Anhui Medical University, Hefei, China.
Frontiers in Immunology
|March 3, 2020
Summary
Natural killer (NK) cell immune checkpoints are emerging targets in cancer immunotherapy. This review comprehensively covers NK cell checkpoints and their therapeutic potential, including dual inhibition strategies.
Area of Science:
- Immunology
- Cancer Biology
- Immunotherapy
Background:
- Cancer immune escape is a significant challenge in treatment.
- Immune checkpoints, particularly on T cells, have been targeted for immunotherapy.
- Natural Killer (NK) cells are a novel and promising target for cancer immunotherapy.
Purpose of the Study:
- To provide a comprehensive review of NK cell-based immune checkpoints.
- To highlight the expanding landscape of identified NK cell checkpoints.
- To explore the therapeutic potential of targeting NK cell checkpoints.
Main Methods:
- Comprehensive literature review of NK cell immune checkpoints.
- Analysis of established and newly identified NK cell checkpoints.
- Exploration of dual-checkpoint inhibition and combination therapies.
Main Results:
- Numerous NK cell immune checkpoints have been identified beyond classical receptors.
- These include CTLA-4, PD-1, B7-H3, LAG-3, TIGIT, CD96, TIM-3, Siglecs, CD200, and CD47.
- Dual-checkpoint inhibition and combination strategies show promise for enhanced efficacy.
Conclusions:
- NK cell immune checkpoints represent a critical area for cancer immunotherapy development.
- Targeting these checkpoints offers new avenues for overcoming immune escape.
- Further research into combination therapies can potentiate antitumor responses.
Related Concept Videos
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
01:27Cytotoxic T Cells-mediated Immune Response
6.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.3K
02:34Inhibition of Cdk Activity
5.5K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
01:28Cells of the Innate Immune Response
8.4K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.4K
01:25Immune Surveillance by NK Cells and Phagocytes
7.7K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.7K