Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality assessment and hydrochemical control mechanism of groundwater in the Hailar Basin.

Environmental geochemistry and health·2026
Same author

Steering Peroxymonosulfate Activation Toward Exclusive Singlet Oxygen Generation via Active Iron Carbides Nanoparticles.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Corrigendum to "Electrically enhanced, Nature-Driven microbial attenuation of chromate and dichloromethane in groundwater" [Bioresour. Technol. 459 (2026) 135175].

Bioresource technology·2026
Same author

Icariside Ⅱ alleviates heart failure based on Wnt/β-catenin-mitochondrial apoptotic pathway.

European journal of pharmacology·2026
Same author

Seasonal Variability and Atmospheric Drivers of Particle-Phase PFAS in PM<sub>2.5</sub> near a Municipal Solid Waste Incineration Facility in Nanchang, China.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Systematic review and meta-analysis of balance training in children with developmental disorders.

PeerJ·2026

Related Experiment Video

Updated: Dec 27, 2025

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

3.9K

epiCOLOC: Integrating Large-Scale and Context-Dependent Epigenomics Features for Comprehensive Colocalization

Yao Zhou1, Yongzheng Sun1, Dandan Huang1

  • 1Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.

Frontiers in Genetics
|March 3, 2020
PubMed
Summary

This study introduces epiCOLOC, a web portal for analyzing epigenomic data. It enables context-dependent colocalization analysis across diverse human tissues and cell types, aiding genomic interpretation and disease research.

Keywords:
cell type specificcolocalizationepigenomics and epigeneticsfunctional annotation analysisgenetic variantsweb server

More Related Videos

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.9K
High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.7K

Related Experiment Videos

Last Updated: Dec 27, 2025

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

3.9K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.9K
High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.7K

Area of Science:

  • Genomics and Epigenomics
  • Computational Biology
  • Bioinformatics

Background:

  • High-throughput epigenomic assays (ChIP-seq, DNase-seq, ATAC-seq) have generated vast datasets of functional genomic elements across human tissues.
  • Interpreting these elements in a context-dependent manner is crucial for understanding human genome function and disease mechanisms.
  • Existing colocalization methods have limitations in scope and predefined feature sets.

Purpose of the Study:

  • To develop a comprehensive resource for context-dependent colocalization analysis of human epigenomic data.
  • To facilitate the identification of functional relationships between genomic regions and epigenomic features.
  • To provide a user-friendly web portal for exploring complex genomic interactions.

Main Methods:

  • Collected and integrated over 44,385 bulk and single-cell epigenomic assays from 53 human tissues/cell types.
  • Classified epigenomic profiles hierarchically by tissue/cell type.
  • Developed the epiCOLOC web portal for performing colocalization analyses.

Main Results:

  • Comprehensive integration of diverse epigenomic data, including transcription factor binding, histone modifications, open chromatin, and transcriptional events.
  • Hierarchical classification enables context-specific analysis of genomic elements.
  • The epiCOLOC portal offers a convenient platform for researchers to conduct epigenomic colocalization studies.

Conclusions:

  • The epiCOLOC web portal provides a powerful and accessible tool for context-dependent epigenomic colocalization analysis.
  • This resource enhances the interpretation of the human genome and its relationship to disease.
  • Facilitates discovery of underlying biological functions and intricate relationships within genomic regions.