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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Cells of the Innate Immune Response01:28

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Updated: Dec 27, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
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NK Cells Regulate CD8+ T Cell Mediated Autoimmunity.

Philipp A Lang1,2,3, Sarah Q Crome4,5, Haifeng C Xu1,3

  • 1Princess Margaret Cancer Centre, Campell Family Institute for Breast Cancer Research, University Health Network (UHN), Toronto, ON, Canada.

Frontiers in Cellular and Infection Microbiology
|March 3, 2020
PubMed
Summary
This summary is machine-generated.

High doses of lymphocytic choriomeningitis virus (LCMV) impair CD8+ T cell responses by increasing NK cell activity. This NK cell-mediated suppression, via NKp46, prevents autoimmune diabetes in RIP-GP mice.

Keywords:
CTLIFN-αLCMVautoimmunitypathology

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Area of Science:

  • Immunology
  • Virology
  • Pathology

Background:

  • Understanding immune regulation is crucial for treating autoimmune diseases and cancer.
  • Natural Killer (NK) cells can modulate CD8+ T cell responses during viral infections.

Purpose of the Study:

  • To investigate the role of NK cells in regulating CD8+ T cell-mediated autoimmune pathology induced by lymphocytic choriomeningitis virus (LCMV).
  • To identify the specific mechanisms by which NK cells suppress T cell responses at different LCMV doses.

Main Methods:

  • Utilized RIP-GP mouse model expressing LCMV glycoprotein on beta-islet cells.
  • Administered varying doses of LCMV (LCMV-WE).
  • Assessed CD8+ T cell responses, NK cell activity, NKp46 expression, and induced diabetes.
  • Employed NK cell depletion (anti-NK1.1 antibodies) and NKp46-deficient (Ncr1-/-) mice.

Main Results:

  • Low-dose LCMV-WE induced robust CD8+ T cell responses and diabetes.
  • High-dose LCMV infection impaired CD8+ T cell responses and prevented diabetes.
  • Increased NK cell activity and NKp46 expression were observed with high-dose LCMV.
  • NK cell depletion or NKp46 deficiency restored CD8+ T cell immunity and permitted diabetes induction with high-dose LCMV.

Conclusions:

  • Innate lymphoid cells, specifically NK cells, can exert regulatory functions to suppress CD8+ T cell-mediated autoimmune pathology.
  • The NKp46 receptor is a key mediator of this T cell suppression.
  • Identified conditions where NK cells interfere with T cell-driven tissue-specific pathology via an NKp46-dependent mechanism.