Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Common Respiratory Disorders

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Acute Respiratory Failure-II

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:

Acute Respiratory Failure-V

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increased dementia diagnosis and workup in primary care with a bilingual screening tool integrated in the electronic health record.

Journal of Alzheimer's disease : JAD·2026

Same author

Advancing precision health discovery in a genetically diverse health system.

Cell·2026

Same author

Combinations of Favipiravir with Doxycycline, Azithromycin or Ivermectin Exert Synergistic Effects Against Influenza A H3N2 Virus Replication.

Pathogens (Basel, Switzerland)·2026

Same author

Automated Image Registration Method for In Vivo Confocal Microscopy of the Corneal Sub-basal Nerve Plexus.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026

Same author

Glucocorticoids regulate the human non-coding genome.

bioRxiv : the preprint server for biology·2025

Same author

Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer's disease.

Scientific reports·2025

Same journal

An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations.

Frontiers in cell and developmental biology·2026

Same journal

Longitudinal changes in the phenotypic profile of circulating extracellular vesicles in healthy individuals.

Frontiers in cell and developmental biology·2026

Same journal

Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications.

Frontiers in cell and developmental biology·2026

Same journal

CD109 exhibits a dynamic expression pattern in coronary endothelium and endocardial-derived valve mesenchyme during heart development with preserved morphogenesis following endothelial-specific deletion.

Frontiers in cell and developmental biology·2026

Same journal

Significance of fatty acid metabolism regulators in the diagnosis and subtype classification in non-alcoholic fatty liver disease.

Frontiers in cell and developmental biology·2026

Same journal

Tumor suppressor network dysregulation in neuroblastoma: molecular mechanisms and precision therapeutic opportunities.

Frontiers in cell and developmental biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 27, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

CD151 in Respiratory Diseases.

Amanda H Wong¹, Thai Tran¹

¹Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Frontiers in Cell and Developmental Biology

|March 3, 2020

Summary

This summary is machine-generated.

Cluster of Differentiation 151 (CD151) plays a key role in lung diseases like cancer and asthma. Understanding CD151's function and regulation is crucial for developing new diagnostic and therapeutic strategies for lung conditions.

Keywords:

CD151 asthma biomarker idiopathic pulmonary fibrosis influenza lung cancer targeted therapy tetraspanin

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

In vivo Evaluation of Mucociliary Clearance in Mice

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Related Experiment Videos

Last Updated: Dec 27, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

In vivo Evaluation of Mucociliary Clearance in Mice

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

Area of Science:

Immunology
Molecular Biology
Pulmonology

Background:

Cluster of Differentiation 151 (CD151) is a tetraspanin protein found in adult tissues, particularly the lungs.
CD151 is implicated in various lung pathologies including lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF).
It interacts with integrins and growth factor receptors, influencing cancer progression and other disease mechanisms.

Purpose of the Study:

To review the current knowledge of CD151's role in lung pathophysiology.
To summarize factors regulating CD151 expression.
To identify CD151's potential as a biomarker and therapeutic target for lung diseases.

Main Methods:

Literature review of studies on CD151 in lung diseases.
Analysis of CD151's interactions with cellular components.
Examination of CD151's association with disease severity and outcomes.

Main Results:

CD151 is involved in tumor initiation, metastasis, and angiogenesis in lung cancer.
In asthma, CD151 promotes airway hyperresponsiveness via calcium signaling.
CD151 acts as a host factor in influenza viral export and is linked to worse outcomes in asthma and lung cancer.

Conclusions:

CD151 significantly contributes to lung pathophysiology across various diseases.
Regulation of CD151 expression is influenced by multiple factors.
CD151 presents potential as a screening, prognostic, or therapeutic target for lung diseases.