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Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

587
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
587
Aging01:26

Aging

518
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
518
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
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Early Vascular Aging in Hypertension.

Peter M Nilsson1

  • 1Skane University Hospital, Lund University, Malmö, Sweden.

Frontiers in Cardiovascular Medicine
|March 3, 2020
PubMed
Summary

Early Vascular Aging (EVA) is a condition characterized by arterial stiffness, increasing cardiovascular risk. Understanding EVA

Area of Science:

  • Cardiovascular research
  • Aging and longevity
  • Vascular biology

Background:

  • Cardiovascular risk and frailty increase with age, leading to conditions like stroke and dementia.
  • Early Vascular Aging (EVA) syndrome, marked by accelerated arterial stiffness, is gaining research attention.
  • Arterial stiffness, a key feature of EVA, is measurable via pulse wave velocity and linked to hypertension.

Purpose of the Study:

  • To explore the multifaceted nature of Early Vascular Aging (EVA) syndrome.
  • To investigate the role of non-hemodynamic factors in arterial stiffness and EVA.
  • To examine the potential of identifying protective mechanisms for novel therapeutic targets.

Main Methods:

  • Assessment of arterial stiffness using pulse wave velocity.
Keywords:
agingarteryglucosehypertensioninflammationoxidative stress

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  • Analysis of non-hemodynamic factors including glucose metabolism, inflammation, and oxidative stress.
  • Exploration of early life programming and birth weight correlations with later vascular health.

    • Main Results:

    • Arterial stiffness in the media layer of large elastic arteries is central to EVA.
    • Non-hemodynamic factors significantly contribute to arterial stiffness and EVA.
    • Early life factors may influence the long-term risk of hypertension and EVA.

    Conclusions:

    • EVA syndrome represents an accelerated aging process impacting vascular health.
    • Lifestyle interventions and conventional treatments may be insufficient for EVA, necessitating new drug development.
    • Identifying protective mechanisms in Healthy Vascular Aging (HVA) and SUPERNOVA phenotypes offers potential for preventive therapies.