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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Heledd H Jarosz-Griffiths1,2, Thomas Scambler2,3, Chi H Wong2,3

  • 1Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

Elife
|March 3, 2020
PubMed
Summary

Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators reduce the exaggerated inflammatory response in cystic fibrosis patients. These drugs decrease key inflammatory markers, suggesting potential clinical benefits beyond improved CFTR function.

Keywords:
cystic fibrosishumanimmunologyinflammationivacaftorlumacaftornlrp3 inflammasometezacaftor

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