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Association between antibiotic use and the risk of rheumatoid arthritis: A protocol for a systematic review
Tingting Meng1, Shibin Zhang1, Dawei Wang2
1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau.
Background:
The potential association between antibiotic use and the risk of rheumatoid arthritis (RA) has drawn significant attention from clinicians and researchers in recent years due to the wild usage of antibiotic. This study aimed to perform a systematic review and meta-analysis of the literature to determine if antibiotic use is associated with an increased risk of RA, so as to provide an important reference for clinical decision-making.
Methods:
Case-control and nest case-control studies of assessing whether antibiotic use is associated with the onset of RA will be identified in searches of 4 databases from their inception to August 2019. All data were assessed and extracted by 2 authors independently. The Newcastle-Ottawa scale was used to assess the quality of the selected studies. Manager Software 5.3 from Cochrane Collaboration (London, UK) and Stata 15.1 (Stata Corp, College Station, TX) will be used to conduct meta-analysis, determining pooled odds ratios and evaluating heterogeneity between studies.
Result:
The results of this systemic review and meta-analysis will be submitted to a recognized journal for publication.
Conclusion:
This systemic review and meta-analysis will determine if antibiotic use is associated with an increased risk of RA. We hope this study can make a definitive conclusion for the association.
Insights
This systematic review and meta-analysis investigates the link between antibiotic use and rheumatoid arthritis (RA) risk. Findings will clarify if antibiotic exposure increases the likelihood of developing RA.
Area of Science:
- Rheumatology
- Epidemiology
- Pharmacology
Background:
- Growing concerns regarding widespread antibiotic use and potential health implications.
- Significant clinical and research interest in the association between antibiotic exposure and rheumatoid arthritis (RA).
Purpose of the Study:
- To systematically review and meta-analyze existing literature on antibiotic use and rheumatoid arthritis risk.
- To provide evidence-based insights for clinical decision-making regarding antibiotic prescriptions and RA prevention.
Main Methods:
- Comprehensive search of four databases (inception to August 2019) for case-control and nested case-control studies.
- Independent data extraction and quality assessment using the Newcastle-Ottawa scale.
- Meta-analysis using Manager Software 5.3 and Stata 15.1 to determine pooled odds ratios and assess heterogeneity.
Main Results:
- Results are pending publication in a peer-reviewed journal.
- The meta-analysis will quantify the association between antibiotic use and rheumatoid arthritis incidence.
Conclusions:
- This study aims to establish a definitive conclusion on the relationship between antibiotic use and rheumatoid arthritis.
- Findings will inform public health strategies and clinical guidelines concerning antibiotic stewardship.
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