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Primary IgA-mediated Autoimmune Hemolytic Anemia in an Infant Successfully Treated With Rituximab
Machiel van den Akker1,2, David Smolders3, Sarah Mahieu3
1Department of Pediatrics, Queen Paola Children's Hospital.
Abstract:
Autoimmune hemolytic anemia (AIHA) is uncommon in the pediatric population and is often associated with an infectious etiology or postvaccination. Mostly, the child presents with a positive direct antiglobulin test. The diagnosis can be challenging, as in our case with an immunoglobulin A-mediated AIHA. In addition to supportive therapy, such as a red blood cell transfusion, steroids are the first choice of treatment. Rituximab, as second-line treatment, can be given in conjunction. We report the first case of immunoglobulin A-mediated AIHA treated with rituximab in the literature.
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