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Breeze: an integrated quality control and data analysis application for high-throughput drug screening.

Swapnil Potdar1, Aleksandr Ianevski1,2, John-Patrick Mpindi1

  • 1Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

Bioinformatics (Oxford, England)
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Summary

Breeze is a new open-source application for quality control and data analysis of high-throughput screening (HTS) data. It reliably identifies drug sensitivity patterns for precision medicine, improving HTS data interpretation.

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Area of Science:

  • Computational biology
  • Bioinformatics
  • Drug discovery

Background:

  • High-throughput screening (HTS) generates large datasets for drug discovery but is prone to experimental errors.
  • Robust quality control (QC) and data analysis are essential for accurate interpretation of HTS results.
  • Existing tools may lack integrated solutions for QC, analysis, and visualization.

Purpose of the Study:

  • To implement an open-source application, Breeze, for integrated quality control and data analysis of HTS data.
  • To provide a reliable method for identifying drug sensitivity and resistance patterns in cell lines and patient-derived samples.
  • To support functional precision medicine applications through accurate drug response quantification.

Main Methods:

  • Development of the Breeze application, an integrated software solution for HTS data.
  • Implementation of robust quality control procedures within the application.
  • Integration of dose-response curve fitting, drug response quantification, and interactive visualization tools.

Main Results:

  • Breeze provides a comprehensive solution for HTS data quality assessment and analysis.
  • The application enables reliable identification of individual drug sensitivity and resistance profiles.
  • Interactive visualization facilitates interpretation of drug responses for precision medicine.

Conclusions:

  • Breeze offers a valuable open-source tool for enhancing the reliability and interpretability of HTS data.
  • The application supports functional precision medicine by enabling precise drug response analysis.
  • Breeze improves the efficiency and accuracy of drug discovery and therapeutic agent development.