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Updated: Dec 27, 2025

Femoral Vascular Graft Implantation in a Swine Model to Test Small-Diameter Vascular Grafts
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Swine Disease Models for Optimal Vascular Engineering.

Michael Sturek1,2, Mouhamad Alloosh1, Frank W Sellke3

  • 1Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA;

Annual Review of Biomedical Engineering
|March 3, 2020
PubMed
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Ossabaw miniature swine models closely mimic human metabolic syndrome and atherosclerosis, offering valuable insights for developing new treatments for these widespread diseases.

Area of Science:

  • Comparative pathology
  • Translational medicine
  • Vascular biology

Background:

  • Obesity, metabolic disease, and diabetes are global health epidemics.
  • Human metabolic and vascular pathophysiology require accurate animal models for research.
  • Swine models offer a high-fidelity platform for studying human diseases.

Purpose of the Study:

  • To review the utility of swine models for studying human metabolic and vascular diseases.
  • To highlight the similarities between Ossabaw miniature swine and humans with metabolic syndrome and atherosclerosis.
  • To discuss the strengths and weaknesses of swine models in biomedical research.

Main Methods:

  • Review of existing literature on swine disease models.
  • Focus on Ossabaw miniature swine for metabolic syndrome and atherosclerosis.
Keywords:
Ossabaw miniature swinecalcificationcoronary arterymetabolic syndromeobesitypositron emission tomography

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  • Analysis of vascular imaging and engineering applications in swine models.

    • Main Results:

    • Ossabaw miniature swine exhibit remarkable similarity to humans with metabolic syndrome and atherosclerosis.
    • Swine models are particularly relevant for coronary artery disease but applicable to all vascular beds.
    • Vascular imaging in swine represents an advancement in vascular engineering.

    Conclusions:

    • Swine models, especially Ossabaw pigs, are crucial for advancing human medicine, particularly in metabolic and vascular diseases.
    • Despite infrastructure challenges, opportunities exist for gene editing and molecular studies in swine models.
    • Swine models facilitate rapid translation of research findings and device testing to human clinical studies.