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Related Experiment Videos

Conditioned place preference produced by intra-hippocampal morphine.

W A Corrigall1, M A Linseman

  • 1Neurobiology Section, Addiction Research Foundation, Toronto, Ontario, Canada.

Pharmacology, Biochemistry, and Behavior
|July 1, 1988
PubMed
Summary

Morphine sulphate injections into the rat hippocampus induced a conditioned place preference. This suggests the hippocampus may play a role in reward or habituation processes.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

Background:

  • The hippocampus is implicated in learning and memory.
  • Its role in reward and motivation is less understood.

Purpose of the Study:

  • To investigate the hippocampus's role in conditioned place preference.
  • To explore potential reward or habituation functions of the hippocampus.

Main Methods:

  • Unilateral microinjections of morphine sulphate into the rat hippocampus.
  • Control group received equi-volume saline injections.
  • Assessed conditioned place preference.

Main Results:

  • Morphine sulphate microinjections produced a significant conditioned place preference.

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  • Saline injections had no effect on place preference.

    • Conclusions:

    • The hippocampus appears to mediate the rewarding effects of morphine.
    • These findings support a role for the hippocampus in reward and/or habituation.