Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

1.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.8K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

21.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
21.7K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

16.2K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
16.2K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

4.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.1K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

17.9K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
17.9K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.2K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physicochemical design of nanobiomaterials in oncology: structure-to-function principles for sequential transport and delivery.

Frontiers in oncology·2026
Same author

Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the NCI'S Nanotechnology Characterization Laboratory Service to the Research Community.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2025
Same author

TooManyCellsInteractive: A visualization tool for dynamic exploration of single-cell data.

GigaScience·2024
Same author

Lipids associated with atherosclerotic plaque instability revealed by mass spectrometry imaging of human carotid arteries.

Atherosclerosis·2024
Same author

Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer.

Molecular cancer·2024
Same author

Iontophoresis-coupled rapidly dissolving polymeric microneedle patch of naloxone for its enhanced transdermal delivery.

International journal of pharmaceutics·2024
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.5K

A modeling platform for the lymphatic system.

Javier Ruiz-Ramírez1, Arturas Ziemys1, Prashant Dogra1

  • 1Mathematics in Medicine Program, The Houston Methodist Research Institute, HMRI R8-122, 6670 Bertner Ave., Houston, TX 77030 USA.

Journal of Theoretical Biology
|March 3, 2020
PubMed
Summary
This summary is machine-generated.

This new physiologically-based pharmacokinetic modeling platform simulates therapeutic agent biodistribution and immune interactions. It accurately models immune cell balance, antigen response, and tumor infiltration for immunotherapy research.

Keywords:
CancerImmunotherapyLymphatic systemMathematical modelingPhysiologically-based pharmacokinetic modeling

More Related Videos

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

18.0K
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

506

Related Experiment Videos

Last Updated: Dec 27, 2025

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.5K
Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo

Published on: May 20, 2011

18.0K
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

506

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Immunology
  • Computational Biology

Background:

  • Understanding therapeutic agent biodistribution and immune system interactions is crucial for developing effective immunotherapies.
  • Current models often lack the spatial heterogeneity and dynamic interactions required to accurately predict agent behavior in complex biological systems like tumors.

Purpose of the Study:

  • To develop and validate a physiologically-based pharmacokinetic modeling platform for simulating therapeutic agent biodistribution, immune interactions, and tumor infiltration.
  • To create a flexible tumor compartment model that accounts for spatial heterogeneity, necrosis, and varying infiltration capacities.

Main Methods:

  • Development of a transport-based pharmacokinetic modeling platform incorporating immune system interactions and lymphoid compartment redistribution.
  • Implementation of a spatially heterogeneous tumor compartment to model tumors of varying size, necrotic state, and agent infiltration capacity.
  • Validation through three examples and exploration through three additional case studies demonstrating model capabilities.

Main Results:

  • The model successfully recapitulates immune cell balance across different physiological compartments.
  • Simulations demonstrate the platform's ability to respond to antigen stimulation and model immune vaccine effects.
  • The model accurately predicts immune cell infiltration into tumor tissues, considering spatial heterogeneity.

Conclusions:

  • The developed physiologically-based pharmacokinetic modeling platform is a valuable tool for studying immunotherapies.
  • The platform's ability to simulate complex biological transport and interactions has the potential to advance medical techniques reliant on biological species transport.