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Mild changes in the mucosal microbiome during terminal ileum inflammation
Hui-Ning Fan1, Pei Zhu1, Yun-Min Lu1
1Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Microbial Pathogenesis
|March 3, 2020
Summary
Terminal ileum inflammation is linked to changes in gut bacteria. Researchers found lower Bacteroidetes and higher Proteobacteria and Lentisphaerae in inflamed ileums, indicating partial dysbiosis.
Area of Science:
- Gastroenterology
- Microbiology
- Inflammatory Bowel Disease Research
Background:
- Terminal ileum inflammation significantly impacts patient morbidity.
- The role of the intestinal microbiota in chronic intestinal inflammation is increasingly recognized.
- However, the specific microbial signatures in the terminal ileum, especially during inflammation, remain understudied.
Purpose of the Study:
- To investigate the composition and diversity of the mucosa-associated microbiota in the terminal ileum.
- To identify microbial differences between individuals with and without terminal ileum inflammation.
- To enhance understanding of the mechanisms driving terminal ileum inflammation.
Main Methods:
- 16S rRNA sequencing was employed to analyze the terminal ileum mucosa-associated microbiota.
- Mucosal biopsies were obtained from 30 patients (15 with inflammation, 15 controls) during colonoscopy.
- Bioinformatics analyses were performed to determine microbial composition and diversity.
Main Results:
- The most abundant phyla in the terminal ileum were Fusobacteria, Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria.
- Patients with inflammation showed a lower relative abundance of Bacteroidetes compared to controls.
- An increased abundance of Proteobacteria and Lentisphaerae was observed in patients with inflammation.
Conclusions:
- Partial dysbiosis of the intestinal mucosa-associated microbiota is associated with terminal ileum inflammation.
- These findings contribute to understanding the microbial contribution to ileal inflammation.
- Further research into the specific roles of these microbial shifts is warranted.
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