Effect of absorbents on permeation of norfloxacin

Norfloxacin is a very potent drug. Adsorption of this drug may account for a significant fraction of total dose, hence the adsorption effect is of great significance. In the present investigation adsorption interaction study various adsorbents, was undertaken using, viz., activated charcoal, bentonite, kaolin, potato starch, talc and lactose by permeation technique. It was observed that forces through which the adsorption interaction is mediated are important to the effect obtained in vitro and that with further knowledge it may be possible to predict in vivo effect from the results of in vitro findings.