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CO-mediated cytoprotection is dependent on cell metabolism modulation
Cláudia Figueiredo-Pereira1, Daniela Dias-Pedroso2, Nuno L Soares2
1CEDOC, Faculdade de Ciência Médicas/NOVA Medical School, Universidade Nova de Lisboa, 1169-056, Lisboa, Portugal.
Redox Biology
|March 3, 2020
Summary
Carbon monoxide (CO), a gasotransmitter, offers cytoprotective effects by regulating cell metabolism. It influences mitochondrial function and metabolic pathways, showing promise for treating metabolic diseases like obesity and diabetes.
Area of Science:
- Biochemistry
- Cell Biology
- Metabolic Regulation
Background:
- Carbon monoxide (CO) is an endogenous gasotransmitter produced by heme oxygenase.
- CO exhibits diverse cytoprotective functions, including anti-apoptosis and anti-inflammation.
- Its role in cellular metabolism and disease is an active area of research.
Purpose of the Study:
- To review and discuss the regulatory mechanisms of carbon monoxide on cell metabolism.
- To elucidate the involvement of CO in its various cytoprotective roles.
- To explore the potential of CO in managing metabolic diseases.
Main Methods:
- Literature review of studies on carbon monoxide's metabolic effects.
- Analysis of research on CO's impact on mitochondrial function.
- Examination of CO's influence on glycolysis and the pentose phosphate pathway.
Main Results:
- CO increases cellular ATP production and modulates mitochondrial activity (ROS generation, biogenesis, oxidative phosphorylation, uncoupling).
- CO negatively regulates glycolysis while enhancing the pentose phosphate pathway.
- CO demonstrates potential in managing metabolic diseases such as obesity and diabetes.
Conclusions:
- Carbon monoxide plays a significant role in regulating cellular metabolism and exerts cytoprotective effects.
- Mitochondria are key targets of CO action, influencing energy production and cellular stress responses.
- CO holds therapeutic promise for metabolic disorders, warranting further investigation.
Keywords:
Carbon monoxideGlycolysisMetabolismMitochondrial biogenesisOxidative phosphorylationPentose phosphate pathwayROS signalingMore Related Videos
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