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Updated: Dec 27, 2025

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression
Humeyra Nur Kaleli1, Ebru Ozer1, Veysel Ogulcan Kaya1
1Molecular Biology, Genetics and Bioengineering Program, Sabanci University, 34956 Istanbul, Turkey.
Abstract:
Protein kinase C (PKC) isozymes are members of the Serine/Threonine kinase family regulating cellular events following activation of membrane bound phospholipids. The breakdown of the downstream signaling pathways of PKC relates to several disease pathogeneses particularly neurodegeneration. PKC isozymes play a critical role in cell death and survival mechanisms, as well as autophagy. Numerous studies have reported that neurodegenerative disease formation is caused by failure of the autophagy mechanism. This review outlines PKC signaling in autophagy and neurodegenerative disease development and introduces some polyphenols as effectors of PKC isozymes for disease therapy.
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