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Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique.
Yan Yang1, Yanjun Zhou1, Xiao Lin1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310058, China.
Pharmaceutics
|March 4, 2020
Summary
Digital light processing (DLP) 3D printing effectively creates personalized medical devices. This study optimized DLP parameters to fabricate functional external and internal structures for drug delivery and physiological applications.
Area of Science:
- Biomaterials Science
- Additive Manufacturing
- Medical Device Fabrication
Background:
- Desktop digital light processing (DLP) 3D printing offers high efficiency and accessibility.
- Its potential in personalized medicine necessitates detailed evaluation for fabricating medical samples.
- Understanding the impact of material composition and printing parameters is crucial for optimizing DLP applications.
Purpose of the Study:
- To fabricate and assess medical samples with external and internal structures using DLP 3D printing.
- To investigate the influence of additives and printing parameters on printability and functionality.
- To determine optimal conditions for creating functional medical implants and physiological channels.
Main Methods:
- Systematic evaluation of poly(ethylene glycol) diacrylate (PEGDA) concentration, plasticizers, layer height, and exposure time.
- Optimization of photoabsorber and tartrazine concentrations for internal structure fabrication.
- Assessment of printability, mechanical properties, drug-loading ability, release characteristics, morphology, integrity, and perfusion behavior.
Main Results:
- Printability and mechanical properties of external structures were influenced by PEGDA concentration, plasticizers, layer height, and exposure time.
- Optimal conditions for external structures involved 100% PEGDA, while internal structures benefited from 75% PEGDA with 0.25 mg/mL tartrazine.
- Optimal layer heights were 0.02 mm for external and 0.05 mm for internal structures, yielding functional drug delivery implants and perfusion-capable channels.
Conclusions:
- DLP 3D printing is a viable technique for fabricating personalized medical implants with drug delivery capabilities.
- Optimized DLP parameters enable the creation of samples with desired morphology, integrity, and physiological functionality.
- This technology holds promise for producing customized implants and in vivo evaluable physiological channels.
