Highly reliable SERS substrate based on plasmonic hybrid coupling between gold nanoislands and periodic nanopillar...

To improve both sensitivity and reliability, a hybrid SERS substrate of combining gold nanoislands (GNI) with periodic MgF₂ nanopillar arrays was successfully developed. SERS detection performance of the proposed substrates was evaluated in terms of enhancement effect, signal-to-noise ratio (SNR), linearity, reproducibility and repeatability, and compared with the performance of a conventional SERS substrate based on GNI. Experimental and simulation results presented that significant improvement of SERS intensity and SNR by more than 3 times and a notable reduction in relative standard deviation were obtained. We hope that the suggested SERS platform with unique advantages in sensitivity and reliability could be extended to point-of-care detection of a variety of biomolecular reactions.