Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

8.6K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
8.6K
Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

8.0K
The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
8.0K
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

4.0K
A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation.

Journal of experimental & clinical cancer research : CR·2019
Same author

Sulfur-Grafted Hollow Carbon Spheres for Potassium-Ion Battery Anodes.

Advanced materials (Deerfield Beach, Fla.)·2019
Same author

Evaluation of incomplete blinking as a measurement of dry eye disease.

The ocular surface·2019
Same author

Evaluation of preoperative anesthesia in patients with mediastinal tumors by cinematic rendering.

Journal of clinical anesthesia·2019
Same author

CRISPR/Cas9-mediated efficient genome editing via protoplast-based transformation in yeast-like fungus Aureobasidium pullulans.

Gene·2019
Same author

Mechanically Reinforced Catechol-Containing Hydrogels with Improved Tissue Gluing Performance.

Biomimetics (Basel, Switzerland)·2019
Same journal

Denoising algorithm of Φ-OTDR systems based on adaptive fractional wavelet transform denoising.

Optics express·2026
Same journal

Millisecond photon-to-photon latency and high-speed volumetric projection system for optogenetics.

Optics express·2026
Same journal

Polarization-encoded coaxial structured light for high-precision 3D surface profilometry.

Optics express·2026
Same journal

Discrete freeform optical design based on collaborative optimization of point cloud and local normals.

Optics express·2026
Same journal

Ultrafast ghost imaging with 25 GHz speckle switching and wavelength-division multiplexing.

Optics express·2026
Same journal

Atomic vapor cells fabricated by femtosecond laser welding of standard-optical-quality glass.

Optics express·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
04:48

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

3.3K

Does deep learning always outperform simple linear regression in optical imaging?

Shuming Jiao, Yang Gao, Jun Feng

    Optics Express
    |March 4, 2020
    PubMed
    Summary
    This summary is machine-generated.

    Conventional linear regression methods can outperform deep learning for optical imaging, especially with limited training data. Deep learning

    More Related Videos

    Deep Neural Networks for Image-Based Dietary Assessment
    13:19

    Deep Neural Networks for Image-Based Dietary Assessment

    Published on: March 13, 2021

    9.9K
    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
    03:31

    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

    Published on: December 15, 2023

    938

    Related Experiment Videos

    Last Updated: Dec 27, 2025

    Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
    04:48

    Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

    Published on: November 30, 2022

    3.3K
    Deep Neural Networks for Image-Based Dietary Assessment
    13:19

    Deep Neural Networks for Image-Based Dietary Assessment

    Published on: March 13, 2021

    9.9K
    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
    03:31

    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

    Published on: December 15, 2023

    938

    Area of Science:

    • Optical imaging
    • Machine learning
    • Image reconstruction

    Background:

    • Deep learning (DL) is widely used in optical imaging.
    • Limitations of DL in optical imaging are not well-studied.
    • Optical systems are often linear.

    Purpose of the Study:

    • Investigate DL limitations in optical imaging.
    • Compare DL with linear regression methods.
    • Identify optimal methods for optical imaging problems.

    Main Methods:

    • Comparative analysis of deep learning and linear regression.
    • Evaluation on two black-box optical imaging problems.
    • Assessment of method performance with varying training sample sizes.

    Main Results:

    • Linear regression outperformed DL in specific optical imaging tasks.
    • DL showed weaknesses with small training datasets.
    • Analysis revealed DL's nonlinearity may be unsuitable for linear systems.

    Conclusions:

    • Linear regression can be superior to DL in certain optical imaging scenarios.
    • DL's effectiveness is data-dependent, particularly with limited samples.
    • Method selection should consider the inherent linearity of optical systems.