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Updated: Dec 27, 2025
08:32
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
Published on: May 23, 2025
977
CRISPR technology for immuno-oncology applications.
Jianbin Wang1, Vitaly Balan1, Francesco Marincola1
1Refuge Biotechnologies Inc., Menlo Park, CA, United States.
Methods in Enzymology
|March 4, 2020
Summary
CRISPR gene editing accelerates cancer immunotherapy development. This review covers CRISPR applications in identifying cancer targets, creating models, and improving cell therapies for better cancer treatment.
Area of Science:
- Biomedical research
- Genetics
- Immunology
Background:
- CRISPR technology has revolutionized biomedical research.
- Cancer immunotherapy offers new hope for treating cancer patients.
- Combining CRISPR with immuno-oncology can speed up cancer therapy development.
Purpose of the Study:
- To review the CRISPR system and its applications in immuno-oncology.
- To highlight CRISPR's role in identifying immune-oncology gene targets.
- To discuss CRISPR's use in generating cancer models and enhancing cell therapies.
Main Methods:
- Literature review of CRISPR technology.
- Analysis of CRISPR applications in cancer immunotherapy research.
- Synthesis of current advancements and future directions.
Main Results:
- CRISPR enables precise identification of immune-oncology gene targets.
- CRISPR facilitates the creation of more accurate animal models for cancer research.
- CRISPR technology improves the design and manufacturing of cells for adoptive cellular therapies.
Conclusions:
- CRISPR is a powerful tool for advancing cancer immunotherapy.
- The integration of CRISPR and immuno-oncology holds significant promise for future cancer treatments.
- Further research will likely uncover more innovative applications of CRISPR in oncology.
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