Related Experiment Video
Updated: Dec 27, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
Published on: January 31, 2020
REPORT- Anti-inflammatory effect of austroyunnane B on RAW264.7 cells
Lan Liu1, Jinyang Zhang1, Baocai Li1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Abstract:
Austroyunnane B, a highly oxidized guaianolide-type sesquiterpenoid isolated from the whole plants of Artemisia austro-yunnanensis by our group, revealed significant inhibition against NO production on the model of lipopolysaccharide (LPS)-stimulated RAW264.7 cells. In this study, its anti-inflammatory effect on some inflammatory cytokines and proteins was further evaluated using the same model. As results, co-treatment with different concentrations (0.39-100μmol /L) of austroyunnane B on LPS-induced RAW264.7 cells displayed reduction of the nitric oxide (NO) generation in a dose dependent manner. It also showed a concentration-dependent inhibition against TNF-α, IL-1β, IL-6 and IL-10, and down-regulation of protein expressions of iNOS and COX-2 on that model at the range of 0.625-10μmol/L, suggesting that austroyunnane B can be used as a lead compound for the development of inflammatory drug.
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The JAK-STAT Signaling Pathway

