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Long noncoding RNA TRPM2-AS acts as a microRNA sponge of miR-612 to promote gastric cancer progression and

Jian Xiao1, Linling Lin1, Dakui Luo2

  • 1Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Oncogenesis
|March 4, 2020
PubMed

Insights

Long noncoding RNA TRPM2-AS promotes gastric cancer (GC) progression and radioresistance. Targeting TRPM2-AS may offer new therapeutic strategies for GC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators in tumorigenesis.
  • Dysregulation of lncRNAs is common in various cancers, including gastric cancer (GC).

Purpose of the Study:

  • Identify critical lncRNAs in GC.
  • Investigate the role and mechanism of TRPM2-AS in GC progression and radioresistance.

Main Methods:

  • Screened The Cancer Genome Atlas Program (TCGA) database for lncRNA expression in GC.
  • Performed in vitro experiments to assess the functional impact of TRPM2-AS.
  • Utilized microRNA sponge assays to elucidate the molecular mechanism.

Main Results:

  • TRPM2-AS is upregulated in GC tissues and associated with advanced stages and poor prognosis.
  • TRPM2-AS silencing inhibits GC cell proliferation, metastasis, and radioresistance.
  • TRPM2-AS acts as a ceRNA for miR-612, upregulating IGF2BP1 and FOXM1, promoting GC progression and radioresistance.

Conclusions:

  • TRPM2-AS, miR-612, IGF2BP1, and FOXM1 form a regulatory axis crucial for GC tumorigenesis.
  • TRPM2-AS represents a potential diagnostic biomarker and therapeutic target for GC.

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