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Comprehensive review of ASC structure and function in immune homeostasis and disease

Ishan Agrawal1, Sushmita Jha2

  • 1Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, NH 65, Nagaur Road, Karwad, Jodhpur, Rajasthan, 342037, India.

Molecular Biology Reports
|March 4, 2020
PubMed

Insights

Apoptosis associated speck-like protein containing CARD (ASC) is an adaptor protein crucial for inflammasome assembly and pyroptosis. This review details its structure, expression, and roles in diseases like cancer and infections.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Apoptosis associated speck-like protein containing CARD (ASC) is a key adaptor protein.
  • ASC is essential for inflammasome assembly and pyroptosis.
  • It possesses a bipartite structure with pyrin and CARD domains.

Purpose of the Study:

  • To review the literature on ASC.
  • To summarize its structure, cellular and tissue expression, and localization.
  • To explore ASC's association with various diseases.

Main Methods:

  • Literature review of scientific publications on ASC.
  • Analysis of studies detailing ASC's structure and function.
  • Compilation of data on ASC's expression patterns and disease relevance.

Main Results:

  • ASC's structure facilitates its adaptor function in inflammasome complexes.
  • ASC exhibits differential expression and localization across various cell types and in response to stimuli.
  • ASC is implicated in the pathogenesis and regulation of cancers, bacterial and viral infections, and inflammatory diseases.

Conclusions:

  • ASC is a critical regulator in immune responses and disease processes.
  • Understanding ASC's multifaceted roles is vital for therapeutic strategies.
  • Further research into ASC's precise mechanisms in health and disease is warranted.

Keywords:
ASCCancerInflammasomeInflammationNLRPyroptosis

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