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Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges.

Huayu Liu1, Kun Liu1, Xiao Han1

  • 1Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.

Current Medicinal Chemistry
|March 4, 2020
PubMed
Summary

Cellulose Nanofibrils (CNFs)-based hydrogels offer promising non-toxic, mechanically strong materials for tissue regeneration and wound healing. Further research is needed to overcome challenges for practical clinical applications.

Keywords:
CNFs-based hydrogelsCellulose nanofibrils (CNFs)Young's modulusbiomedical applicationshydrogelnanocellulose

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Cellulose Nanofibrils (CNFs) are natural nanomaterials with unique properties like high mechanical strength and large surface areas.
  • These characteristics make CNFs suitable for advanced applications, particularly in the biomedical field.

Purpose of the Study:

  • This review introduces the preparation methods for CNFs-based hydrogels.
  • It also highlights recent advances in their biomedical applications.

Main Methods:

  • Literature search to summarize CNF preparation (mechanical and chemical-mechanical methods).
  • Overview of CNF-based hydrogel fabrication (metal ion and polymer cross-linking).
  • Summary of biomedical applications, focusing on tissue scaffolds and wound dressings.

Main Results:

  • CNFs-based hydrogels are non-toxic and possess notable mechanical strength.
  • As tissue scaffolds, they create a conducive micro-environment for tissue repair and regeneration.
  • In wound dressings, they protect wounds and promote skin tissue healing.

Conclusions:

  • CNFs-based hydrogels show potential but are currently in the laboratory stage.
  • Further research is required for practical clinical translation.
  • Developing medical hydrogels with superior mechanical properties and biocompatibility remains a significant challenge.