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Updated: Dec 27, 2025
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Placental dysfunction: health status, nutritional status and mineral profile of a mother-child pair
Tetyana V Frolova1, Viktoriya V Lazurenko2, Nana M Pasiyeshvili3
1Department Of Propedeutic Pediatrics No. 1, Kharkiv National Medical University, Kharkiv, Ukraine.
Insights
Pregnancy complications and labor issues are frequent in women with PD (Parkinson's Disease). This condition may lead to mineral imbalances in breastfed infants, affecting their development and health.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Nutritional Science
Background:
- Pregnancy and labor are complex physiological processes influenced by maternal health.
- Maternal mineral homeostasis plays a crucial role in fetal development and infant health.
- Parkinson's Disease (PD) in mothers may impact pregnancy outcomes and infant well-being.
Purpose of the Study:
- To analyze the impact of Parkinson's Disease (PD) on pregnancy and labor.
- To investigate the development and health status of infants born to mothers with PD.
- To assess maternal-fetal nutritional status and mineral homeostasis in mother-infant pairs.
Main Methods:
- A 5-year retrospective analysis of PD, pregnancy, and labor frequency.
- Examination of 188 mother-child pairs, with 84.04% of mothers diagnosed with PD.
- Assessment included anamnestic data, maternal nutritional status, clinical examination, child development evaluation, and elemental profiling.
Main Results:
- High complication rates in pregnancy and labor were observed in mothers with PD, linked to "mother-placenta-fetus" system imbalance.
- Mothers with PD showed elevated levels of Zinc, Potassium, and Calcium in hair, and Potassium, Chromium, and Sodium in breast milk.
- Infants born to mothers with PD exhibited significantly increased levels of Chromium, Sulfur, Phosphorus, Sodium, Calcium, and Zinc.
Conclusions:
- Parkinson's Disease negatively affects pregnancy and labor outcomes.
- PD in mothers is a potential factor contributing to mineral imbalances in breastfed infants.
- Maternal mineral status is critical for infant health, particularly in the context of PD.
Objective:
The aim: the analysis of the PD, pregnancy, the labor, the research on peculiarities of the development and health status of breast-fed children, who are born to mothers with PD, by means of analyzing the mother-child pair's nutritional status and mineral homeostasis.
Patients And Methods:
Materials and methods: At the 1 stage, an analysis of the PD frequency, the pregnancy, the labor was conducted during 5 years. At the 2 stage, 188 mother-child pairs were examined: 84.04% women had PD and 15.96% didn't have it. The research included the analysis of the anamnestic data, maternal nutritional status, general clinical study, assessment of the physical, psychomotor level of the child's development, study of the elemental profile.
Results:
Results: High frequency of complications in pregnancy and labor was observed in cases when women had PD, due to the imbalance in the "mother-placenta-fetus" system. The results' analysis showed an increased level of Zn (1.437%), K (10.147%), and Ca (83.900%) in hair; an increased level of K (82.818%), Cr (0.274%), and Na (3.611%) in breast milk of women with PD. Children born to mothers with PD had a significantly increased level of Cr (0.92%), S (0.578%) and P (0.169%), Na (0.107%), Ca (56.041%), and Zn (7.149%).
Conclusion:
Conclusions: PD has a negative impact on the pregnancy and labor and may be one of the factors causing the mineral imbalance of breast-fed infant.
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