Related Experiment Video

Updated: Dec 27, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.6K

Mitochondrial Sirtuins in Skin and Skin Cancers

Shengqin Su1, Mary Ndiaye1, Chandra K Singh1

  • 1Department of Dermatology, University of Wisconsin, Madison, WI.

Photochemistry and Photobiology
|March 4, 2020
PubMed

Insights

Mitochondrial sirtuins (SIRTs -3, -4, -5) are crucial for skin health, impacting aging, UVR response, and skin cancers. Further research is needed to fully understand their roles in dermatological conditions.

Area of Science:

  • Biochemistry
  • Dermatology
  • Molecular Biology

Background:

  • Mammalian sirtuins (SIRTs 1-7) are NAD+-dependent deacetylases regulating cellular processes.
  • Mitochondrial sirtuins (SIRTs -3, -4, -5) are involved in aging, oxidative stress, and disease.
  • Dysregulation of mitochondrial sirtuins is observed in various skin conditions, including UVR response.

Purpose of the Study:

  • To review the roles and implications of mitochondrial sirtuins in cutaneous cellular processes.
  • To explore the potential of mitochondrial sirtuins as therapeutic targets for skin diseases, including skin cancer.

Main Methods:

  • Literature review focusing on mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) and their functions in skin.
  • Analysis of evidence linking these sirtuins to dermatological conditions such as aging, UVR response, and skin cancers.

Main Results:

  • SIRT3 is extensively studied and linked to keratinocyte differentiation, wound healing, aging, UVR response, and various skin cancers (melanoma, BCC, SCC).
  • SIRT4 is associated with keratinocyte differentiation, aging, UVR response, alopecia, BCC, and SCC.
  • SIRT5 is linked to keratinocyte differentiation, melanoma, BCC, and SCC.

Conclusions:

  • Mitochondrial sirtuins play significant roles in skin homeostasis and disease.
  • Compelling evidence supports their involvement in skin health and cancer, but detailed studies are required to elucidate exact mechanisms.
  • Mitochondrial sirtuins represent promising targets for managing skin diseases and cancer.

More Related Videos

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.6K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

1.7K

Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.3K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
18.2K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
16.4K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.3K