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Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia

JingCheng Zhang1, SaiBin Wang1, YaDong Xue1

  • 1Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China.

Journal of Medical Virology
|March 4, 2020
PubMed

Insights

Nucleic acid detection of COVID-19 in fecal specimens is as accurate as pharyngeal swabs. A positive stool test in patients did not correlate with gastrointestinal symptoms or lung infection severity.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The 2019 novel coronavirus (COVID-19) pandemic has caused a global health crisis.
  • Understanding the diagnostic methods and clinical manifestations of COVID-19 is crucial for effective management.

Purpose of the Study:

  • To evaluate the accuracy of fecal specimens for COVID-19 nucleic acid detection compared to pharyngeal swabs.
  • To investigate the relationship between positive fecal tests, gastrointestinal symptoms, and lung infection severity in COVID-19 patients.

Main Methods:

  • Retrospective analysis of laboratory-confirmed COVID-19 cases.
  • Comparison of COVID-19 nucleic acid detection results from fecal and pharyngeal swab specimens.
  • Correlation analysis between fecal test results, clinical symptoms, and disease severity.

Main Results:

  • Nucleic acid detection of COVID-19 in fecal specimens demonstrated equal accuracy to pharyngeal swab specimens.
  • Patients with positive fecal tests did not exhibit gastrointestinal symptoms.
  • A positive stool test did not correlate with the severity of lung infection.

Conclusions:

  • Fecal specimen testing is a viable and accurate method for COVID-19 diagnosis.
  • Gastrointestinal symptoms are not necessarily indicative of fecal viral shedding.
  • Fecal viral shedding does not appear to be associated with increased COVID-19 lung disease severity.
Keywords:
coronavirusdisseminationnervous systempathogenesisvirus classification

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