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T1ρ magnetic resonance fingerprinting
Cory R Wyatt1,2, Thomas M Barbara1, Alexander R Guimaraes1,2
1Advanced Imaging Research Center, Oregon Health & Sciences University, Portland, Oregon, USA.
NMR in Biomedicine
|March 4, 2020
Summary
This study integrates T1ρ relaxation into magnetic resonance fingerprinting (MRF), enabling simultaneous quantitative mapping of T1, T2, and T1ρ relaxation times. This advanced MRF technique improves tissue quantification and reduces motion artifacts in abdominal imaging.
Area of Science:
- Medical Imaging
- Quantitative MRI
- Biophysics
Background:
- T1ρ relaxation imaging assesses various conditions like fibrosis and tumors.
- T1, T2, and T1ρ relaxation times offer multi-parametric tissue quantification.
- Traditional Magnetic Resonance Fingerprinting (MRF) maps T1 and T2 efficiently.
Purpose of the Study:
- To incorporate T1ρ relaxation into the MRF framework.
- To develop a multi-parametric MRF technique for simultaneous T1, T2, and T1ρ mapping.
- To validate the new MRF sequence against conventional methods.
Main Methods:
- An MRF sequence with T1ρ spin lock preparations was designed.
- The sequence varied TR, flip angle, and T1ρ/T2 preparations.
- Calibration was performed using agar phantoms and volunteer abdominal scans.
Main Results:
- High intraclass correlation coefficients (ICC > 0.9) were observed between MRF and conventional methods in phantoms.
- Strong correlations (ICC > 0.8) were found in healthy volunteers.
- T1 showed the highest correlation, followed by T1ρ, then T2.
Conclusions:
- T1ρ relaxation is successfully integrated into the MRF framework.
- This multi-parametric MRF approach allows simultaneous T1, T2, and T1ρ quantification.
- Acquisition within a single breath-hold minimizes motion artifacts in abdominal imaging.
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