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Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Jimin Xu, Pei-Yong Shi, Hongmin Li1
1Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, New York 12208, United States.
Abstract:
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.
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