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Updated: Dec 27, 2025

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

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CoRESTed development of regulatory T cells

Luisa Morales-Nebreda1, Kathryn A Helmin1, Benjamin D Singer1,2,3

  • 1Division of Pulmonary and Critical Care Medicine.

The Journal of Clinical Investigation
|March 4, 2020
PubMed

Insights

Regulatory T cells (Tregs) need epigenetic marks for immune suppression. Researchers found that CoREST is crucial for Treg function, and its inhibition aids organ transplant tolerance and anti-tumor immunity.

Area of Science:

  • Immunology
  • Epigenetics
  • Molecular Biology

Background:

  • Regulatory T cells (Tregs) are vital for immune homeostasis.
  • Epigenetic modifications are essential for Treg function in inflammation and cancer.
  • Identifying key epigenetic regulators in Tregs is crucial for therapeutic development.

Purpose of the Study:

  • To investigate the role of REST corepressor 1 (CoREST) in Treg function.
  • To determine the impact of CoREST modulation on immune tolerance and anti-tumor immunity.

Main Methods:

  • Genetic manipulation of CoREST in Tregs.
  • Pharmacologic inhibition of CoREST.
  • Assessment of Treg suppressive function.
  • Analysis of organ allograft tolerance.
  • Evaluation of anti-tumor immune responses.

Main Results:

  • CoREST is critical for Treg-mediated immune suppression.
  • Loss of CoREST in Tregs impairs organ allograft tolerance.
  • CoREST inhibition in Tregs unleashes anti-tumor immunity by activating effector T cell programs.
  • CoREST regulates Treg-specific transcriptional programs epigenetically.

Conclusions:

  • CoREST is a key epigenetic regulator of Treg suppressive function.
  • Targeting CoREST in Tregs offers a potential therapeutic strategy for inflammatory diseases and cancer.
  • Exploiting epigenetic control mechanisms in Tregs can advance Treg-based therapies.

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