Direct immersion single-drop microextraction of semi-volatile organic compounds in environmental samples: A review

Single-drop microextraction (SDME) techniques are efficient approaches to pretreatment of aqueous samples. The main advantage of SDME lies in the miniaturization of the solvent extraction process, minimizing the hazards associated with the use of toxic organic solvents. Thus, SDME techniques are cost-effective, and represent less harm to the environment, subscribing to green analytical chemistry principles. In practice, two main approaches can be used to perform SDME - direct immersion (DI)-SDME and headspace (HS)-SDME. Even though the DI-SDME has been shown to be quite effective for extraction and enrichment of various organic compounds, applications of DI-SDME are normally more suitable for moderately polar and non-polar semi-volatile organic compounds (SVOCs) using organic solvents which are immiscible with water. In this review, we present a historical overview and current advances in DI-SDME, including the common analytical tools which are usually coupled with DI-SDME. The review also focuses on applications concerning SVOCs in environmental samples. Currents trends in DI-SDME and possible future direction of the procedure are discussed.