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PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
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Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review.

Adrian Y S Lee1,2

  • 1Department of Allergy/Clinical Immunology and SA Pathology, Flinders Medical Centre, Bedford Park, South Australia, Australia, adrian.lee@flinders.edu.au

International Archives of Allergy and Immunology
|March 4, 2020
PubMed
Summary

Elevated serum tryptase (hypertryptasemia) indicates more than anaphylaxis. This review details non-anaphylactic conditions like systemic mastocytosis and kidney disease, crucial for accurate diagnosis.

Keywords:
AllergyAnaphylaxisDiagnosisMast cellsTryptase

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Area of Science:

  • Clinical immunology
  • Hematology

Background:

  • Mast cell tryptase is a key biomarker in allergy diagnostics.
  • Elevated serum tryptase (hypertryptasemia) is primarily associated with anaphylaxis and mastocytosis.

Purpose of the Study:

  • To comprehensively review non-anaphylactic conditions associated with hypertryptasemia.
  • To increase clinician awareness of differential diagnoses for elevated serum tryptase.

Main Methods:

  • Literature review of studies reporting hypertryptasemia in non-anaphylactic conditions.
  • Synthesis of current evidence on differential diagnoses for elevated serum tryptase.

Main Results:

  • Hypertryptasemia can be observed in systemic mastocytosis, hematological malignancies, and chronic kidney disease.
  • Several non-anaphylactic conditions present with elevated serum tryptase levels.

Conclusions:

  • Clinicians must consider a broader range of differential diagnoses beyond anaphylaxis for elevated serum tryptase.
  • Awareness of non-anaphylactic causes of hypertryptasemia is essential for appropriate patient management.