[Clinical evaluation of biochemical diagnostic studies]

The principles and difficulties of enzyme diagnosis of myocardial infarction, differential diagnostic significance of a study of isoenzymatic activity, and some difficulties of topical diagnosis on the basis of enzymatic tests were considered the light of modern methods of clinical biochemistry. The necessity of enzyme diagnosis was assessed and substantiated. It was shown that the problems of pathobiochemistry of coronary heart disease were not limited to lipoprotein metabolic derangements only; the diagnostic importance of a HDL cholesterol value was assessed. The diagnostic importance of microalbuminuria and the activity of N-acetyl-beta-glucoaminidase in the diagnosis of essential hypertension and symptomatic hypertension was underlined.