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Embedded droplet printing in yield-stress fluids.

Arif Z Nelson1,2, Binu Kundukad1,2, Wai Kuan Wong3

  • 1Biological Systems and Micromechanics, Singapore-MIT Alliance for Research and Technology, 138602 Singapore, Singapore.

Proceedings of the National Academy of Sciences of the United States of America
|March 5, 2020
PubMed
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Embedded droplet printing uses yield-stress fluids to precisely control droplets, enabling experiments in a quiescent state without external interference. This novel microfluidic technique simplifies processes and offers diverse applications.

Area of Science:

  • Fluid Dynamics
  • Materials Science
  • Microfluidics

Background:

  • Microfluidic droplet manipulation is crucial in science and technology.
  • Existing methods rarely leverage non-Newtonian fluid properties like yield-stress behavior.
  • Conventional microfluidics face challenges with external influences and complex device fabrication.

Purpose of the Study:

  • Introduce embedded droplet printing for droplet generation, trapping, and processing within yield-stress fluids.
  • Explore the advantages of manipulating droplets in an "absolutely quiescent" state.
  • Demonstrate a simplified microfluidic approach free from surfactants and complex device manufacturing.

Main Methods:

  • Developed a system for embedded droplet printing using yield-stress fluids.
Keywords:
complex fluidscrystallizationdropletsmicrofluidicsyield-stress fluids

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  • Characterized droplet generation within these fluids using a model system.
  • Defined archetypal operations for droplet manipulation in this novel environment.

    • Main Results:

    • Successfully generated, trapped, and processed droplets within yield-stress fluids.
    • Eliminated exterior influences like convection and solid boundaries for droplet manipulation.
    • Demonstrated the technique's applicability to pharmaceutical crystallization, microbatch chemical reactions, and biological assays.

    Conclusions:

    • Embedded droplet printing offers a unique platform for droplet manipulation in quiescent conditions.
    • The technique overcomes limitations of conventional microfluidics, including surfactant use and device complexity.
    • This method shows significant potential for diverse scientific and technological applications.